The Mechanisms of Vaccine Injury and Via Cytokine Storm

Bron: http://www.vacfacts.info/the-mechanisms-of-vaccine-injury-and-via-cytokine-storm.html

The issue of vaccine injury is somewhat complex, but yet all in all this, the basics are somewhat simply understood. There are essential some basic areas of vaccine reactivity that produce immune responses and adverse effects. One is the cytokine storm activity which all vaccines produce, just as the natural pathogens do. This could more easily be referenced to as the same thing that was produced during the 1918 so called flu pandemic, and was the known basic mechanism that caused large numbers of deaths. It has also been known for example to be the cause in more recent H1N1 related deaths. This is not an all or nothing situation, and there are varied levels of cytokine storm activity, and of course in not all cases does it produce death. In some cases it can produce temporary effects, to more harmful effects that require some major healing, and as well some more profoundly lasting and if not permanent harm done.This will be found outlined below in the information. You will as well realize that much of what is described in the sections below on this page as well fit noticeably well with what is known about the physical/physiological effects of vaccine injury and pathology. They are strikingly similar.

Another aspect to vaccine injury is not only relative to immune response, but as well in regard to the adverse effect of vaccine aluminum adjuvants. Such adjuvants can create blood viscosity changes and sludging of the blood; another term would be found to describe that as being within the terms of Zeta potential, if you were to research and review that, (also a page exists on this site in reference to that issue). This wold be found a complete explanation of, in the largely ignored by mainstream, work that Dr Andrew Moulden did and put forth. (You can as well find that information on this site).

A third component here to that is in regard to the aluminum adjuvants creating an inflammatory effect, which of course is what such adjuvants are known by their pharmacological action to do, and that as well in regard to their intended use being immune system stimulation. This is necessary and so said, to acquire immune system identification of killed/attenuated vaccine antigens; otherwise the immune response would be to naturally weak to mount any antibodies formation. Now, you can start to see this picture. Not only do you have similar reactivity within the immune system that would be typical of natural infection, but as well the added and potentially dysregulated reactivity caused by the aluminum adjuvants.

The forth leg of this is as well the known know in well done studies, potential over activation of the brains microglia cells, and resulting and variable levels of said chronic brain inflammation, and of course and again due to the effect of aluminum adjuvants.

There is no question that chronic levels of unnatural brain inflammation have been and continue to be found in the case of autism. Some studies that are actually mainstream, have found that said inflammation; but however do not suggest a causation, but to call it some sort of inflammatory syndrome. Then yet other studies tie it directly to the aluminum adjuvant effect of vaccines, and of course more specifically the use of multiple vaccines. The study science is all to clearly there; and of course it is being ignored by such as the CDC, and other agencies that should have long ago already, taken a look at that situation but refuse to. Dr Russell Blaylock was putting forth the complete data on that situation already years ago. Several studies since that time have found the same and similar outcome in their data.

Written by a partner vaccine truth advocate: The best thing to do when a vaccine reaction occurs. Take child to the Emergency room and have doctors collect blood sample to evaluate the “cytokine” and specifically look at the inflammatory cytokines, save the info because these lab values document and validate the vaccine reaction in medical and legal arenas. Another area is to have verification to say NO to any more vaccines. In addition, recent studies confirm that kids with autism and ASD have mothers with elevated inflammatory cytokines and kids with autism and ASD have elevated inflammatory cytokines.

Inflammatory Cytokines & Receptors
http://www.qiagen.com/products/genes%20and%20pathways/complete%20biology%20list/inflammatory%20cytokines%20and%20receptors?cmpid=QFDKUS20inflammatorycytokines_Adwords_SEM_NA

Understanding immunity requires more than immunology
http://www.nature.com/ni/journal/v11/n7/full/ni0710-561.html

Anatomy and Physiology of the Immune System, Part 4
How pharmaceuticals destroy nature
http://jonbarron.org/article/anatomy-and-physiology-immune-system-part-4#.UwH0pvldXbY

Why vaccines spread disease and vaccine science is flawed
http://alignlife.com/articles/medicalresearch/why-vaccines-spread-disease-and-vaccine-science-if-flawed

How Do Vaccines Work? Immune Mechanisms and Consequenceshttp://pathwaystofamilywellness.org/component/option,com_crossjoomlaarticlemanager/Itemid,375/aid,1369/view,crossjoomlaarticlemanager/#sthash.rkJSugBv.dpuf

CytoSorbents Corp
http://www.sec.gov/Archives/edgar/data/1175151/000114420412033733/v315508_ex99-1.htm

Benjamin J. Zeller NBC Tolerance Lost Vaccine MASS Hypoxia Ischemia Disease. Mar 19, 2009 

In July 30, 2008 landmark MMR case adjudicated by the United States Vaccine Injury Courts confirms that the vaccine injury courts accept that the MMR vaccination causes ischemia/impaired blood flow and oxygenation to the brain – this is part of the M.A.S.S. and Zeta response as detailed in the Tolerance Lost video series. In the case of Benjamin Zeller, who developed seizures, lost his language, motor, and social skills, young Benjamin ALSO exhibits the same ischemic neurological damages, from vacination, that we also record, following vaccine induced austism, specific learning disabilities, sudden infant death, and much more… Cause-effect is established. For legal action for vaccine induced MASS Hypoxic Ischemic Disease (autism etc…) please contact the following legal counsel from the Benjamin Zeller case that was successfully litigated in the vaccine injury courts. If vaccinations have caused autism and other clinically “silent” ischemic brain injuries – proof causation is now proveable in court.

http://www.youtube.com/watch?v=qXCzVkhHGHg

Vaccines & Overdosed Babies

Is the current immunization schedule safe? Vaccines are drugs. They contain antigens, preservatives, adjuvants, stabilizers, antibiotics, buffers, diluents, emulsifiers, excipients, residuals, solvents, and inactivating chemicals. They also contain residue from animal and human growth mediums. Why are these substances put into vaccines? Why do vaccines contain mercury and aluminum? Why are so many vaccines given at the same time? What effect do they have on the developing child? How common are adverse reactions to vaccines? What is VAERS? Are vaccinations legally required?

http://www.youtube.com/watch?v=s49xpHl3hWI

Lets get started.

Dynamics of a Cytokine Storm

Reading the details the doctor states the baby has sepsis, cause of death meningitis. The parents need to vigorously pursue the vaccine because it IS the cause of death. Sepsis is due to ‘cytokine storm.’ This is the mechanism of vaccine injury. The vaccines house adjuvants; aluminum, formaldehyde for the precise purpose to stimulate the immune system and there is an over response, releasing a bombardment of PRO inflammatory cytokines which result in inflammation of all organ systems, especially, the brain, lungs, results in Multiple Organ Failure (MOF)This validates causation! In addition the multiple vaccines in such a small child, is negligence, if not battery. Giving multiple vaccines at the same time, causes a synergistic effect, when one or more results in the effects to be magnified, thereby, the ingredients can be 100x-1000x the toxicity. The parents should get an attorney and make sure all these tests are performed and obtain copies. Serves as validation in the medical and legal arena’s.

Abstract

Six volunteers experienced severe inflammatory response during the Phase I clinical trial of a monoclonal antibody that was designed to stimulate a regulatory T cell response. Soon after the trial began, each volunteer experienced a “cytokine storm”, a dramatic increase in cytokine concentrations.

Read more:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045027

Cytokine storm can lead to multiple organ failure, infection and death in sepsis and the systemic inflammatory response syndrome

The overproduction of cytokines by the immune system, often called “cytokine storm”, is a hallmark of many life-threatening illnesses seen in the intensive care unit such as severe sepsis and septic shock, acute respiratory distress syndrome (ARDS), trauma, serious burn injury, post-surgical complications, influenza, and severe acute pancreatitis. Cytokine storm can be toxic, causing direct cell death, massive capillary leakage, severe inflammation, and a cascade of events that can ultimately lead to shock and cardiovascular collapse, respiratory, renal and hepatic failure, immune system paralysis, and other problems. Multiple organ failure and secondary infections are two of the leading causes of death in the ICU. Current standard of care therapies are typically supportive care, with little to no “active” therapies to fight cytokine storm.

There is a treatment for cytokine storm if implemented within a specific window of time.

Cytosorb® therapy is gentle, well-tolerated, and has been used in more than 650 human treatments without serious device-related adverse events. Aside from a slight reduction of platelets as seen with all extracorporeal therapies, standard hematology and chemistry panels were unaffected.

Cytosorb® reduces
cytokine storm in critical care illnesses

Cytosorb® is the first-in-class therapy specifically approved as an extracorporeal cytokine filter in the European Union. Its use is broadly indicated where
cytokines are elevated.

http://www.cytosorbents.com/pdf/CytoSorb_Marketing_Brochure_July_2012.pdf

If the patient survives the cytokine storm they wind up with an autoimmune disease.

Have You “Weathered” a Cytokine Storm?

If you are suffering from autoimmune conditions or any confusing mess of symptoms, the answer is ‘Yes’;You have weathered a cytokine storm. Those with autoimmune disorders experience a cytokine storm where bad days are followed by calm days, but something triggers another cytokine storm and another round of bad days. Autoimmune patients, like those with Hashimoto’s or Rheumatoid Arthritis, often refer to these bad days as flare ups.

A good defense against most illness is a healthy immune system. At the first hint of danger, the immune system takes action to protect us. Immune stimulants or physical triggers can be food, toxins, bacteria, virus, parasite, or even stress. Cytokine storms occur when the immune system becomes and remains activated beyond the point of being helpful. “Storm” is an appropriate metaphor because it acknowledges complex conditions and symptoms which occur with immune dysregulation. Some of the primary symptoms of a cytokine storm are extreme fatigue, depression, anxiousness, anxiety, insomnia, intermittent hot flashes, inflammation, tingling, skin conditions, swollen glands, feverish, abdominal pain, and nausea. Each patient has unique triggering events and exhibits a different mix of symptoms.

When the body’s immune system is activated, it is intending to protect the body.However, sometimes the immune response escapes from the normal regulatory controls.Cytokines, which are proteins produced by the immune system, are like text messengers between the nervous system, the immune system, hormones and the gut which regulate cellular response to disease and infection.The manner in which the cytokines are stimulated and balance between the inhibitory and stimulatory neurotransmitters determine the intensity of a cytokine storm and the severity of the patients symptoms.

Elevated levels of cytokines induce a complex, dysregulated condition resulting in massive inflammation and fluid accumulation, blood flow dysfunction and eventually tissue destruction. The overzealous immune response becomes damaging and the patient’s symptoms reflect this in a cytokine storm. Unfortunately, few practitioners look at cytokines as part of the problem within an autoimmune disease process.

Life with an Autoimmune Disease: Cytokine-Induced Sickness Behavior

After a cytokine storm has subsided, sick individuals have common symptoms (body and brain based); such as little motivation to eat, withdraw from normal social activities, fever, burning muscles, aching joints, fatigue or significant changes in sleep patterns. They may display an inability to experience pleasure, have exaggerated responses to pain or brain fog. Although Functional Medicine has defined inflammatory cytokines as the central mediators of sickness behavior, monitoring inhibitory cytokine behavior is often the first step in treating an autoimmune patient.

Read more:
http://www.wellnessalternatives-stl.com/have-you-weathered-a-cytokine-storm/

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The Mechanism of Vaccine Injury

This specific section of information on this page is copyright protected. Please message me for permission to use.

People ask what is the mechanism involved to suspect that vaccines cause harm/death?

Since 1998, my hypothesis has been; the adverse events/deaths associated with/caused by vaccines are the result of over reaction of the immune system; “cytokine storm.”

The vaccine houses not only the specific pathogen, but also adjuvants; aluminum, formaldehyde, mercury, (thimerosal) and all sorts of accompanying ingredients. The immune system interprets these ingredients as ‘foreign agents’ and thus begins the immune response. However, in some instances the immune system ‘over responds’ and this is when trouble occurs.

The vaccine researchers use adjuvants to induce the cytokine response, stimulate the TH 1 and TH 2 response, however, they still are not sure how the mechanism works or which adjuvants offer the best results. Therefore, the inoculation process remains a study of effects. These ingredients create havoc on the fragile immune system. http://www.invivogen.com/review-vaccine-adjuvants

A cytokine storm is the systemic expression of a healthy and vigorous immune system resulting in the release of more than 150 inflammatory mediators (cytokines, oxygen free radicals, and coagulation factors). Both pro-inflammatory cytokines (such as Tumor Necrosis Factor-alpha, InterLeukin-1, and InterLeukin-6) and anti-inflammatory cytokines (such as interleukin 10, and interleukin 1 receptor antagonist) are elevated in the serum, and the fierce and often lethal interplay of these cytokines is referred to as a “Cytokine Storm.” The primary contributors to the cytokine storm are TNF-a (Tumor Necrosis Factor-alpha) and IL-6 (Interleukin-6). The cytokine storm is an inappropriate (exaggerated) immune response that is caused by rapidly proliferating and highly activated T-cells or natural killer (NK) cells. These cells are themselves activated by macrophages. The cytokine storm must be treated and suppressed or lethality can result.

When your child presents with signs/symptoms of vaccine reaction, take them to the ER immediately and ask the physician to order the following blood work to evaluate interleukins, specifically. Pro inflammatory  cytokines.

Get a copy of the lab report and save for your records. These documents serve as proof that the reaction is due to the vaccine.

The allergic response is also involved, mast cells, release of histamine, which I am not going to address in this paper.

The etiology behind the bowel problems is likely due to ‘translocation.’  The gut is our largest immune organ.
Animals and humans are born with an amazing, awesome and intricate immune system. Quite complicated and involved, requiring physicians and scientists to continuously study its action. Cytokine storm can lead to detrimental effects such as leakage from capillaries, tissue edema, organ failure and shock, known as ‘septic shock.’
A cascade of intricate immune functions begin, resulting in organ dysfunction, hypoperfusion (low blood flow) and/or hypotension (low blood pressure), with lactic acid buildup, oliguria, (low urine output) or an acute alteration in mentation. (confusion, stupor, coma).

As the invading foreign agent proliferate within hours or days, it releases mediators and other products that further modulate the immune (defense) response. These substances attack and destroy cell walls, inactivate cellular contents responsible for metabolic processes, and stimulate the inflammatory response throughout the body. There is platelet activation and aggregation, influx of macrophages, proliferation of white cell components (i.e., neutrophils). The result of all this activity is microvascular cell wall permeability and massive vasodilatation. All organs and systems are affected; immediate emergent treatment must take place to prevent detrimental affects, severe disability, even death.

Oxygen free radicals, histamine, complement factor C5a, Beta-endorphin, thromboxane B2, and platelet activating factor cytokines which are implicated are TNF-alpha, IL1, IL6 and IL8. Serum TNF alpha concentrations in excess of 1 ng/mL are frequently predictive of a lethal outcome, however serum concentrations of other inflammatory cytokines involved in the pathophysiology, but not always reliable predictors of the severity of the shock state or clinical outcome. These cytokines are released by macrophages following activation by endotoxins.

Concurrently, the coagulation cascade is also triggered in the attempt to contain the inflammation from the foreign invasion or allergic response to the adjuvants. When cell walls are destroyed, cell activity becomes deranged as cell contents leak out; there is microvascular clotting and massive inflammation. As organs succumb to this deadly cascade of events, the domino effect topples several organs one by one, resulting in multiple organ dysfunctions. (MODS)
There are numerous conditions that trigger this immune response. Primarily, the very young, very old, immunocompromised or those patients with chronic medical conditions become highly susceptible to even a minute exposure of the foreign agent or introduction to an irritant adjuvant. Other situations that may predispose a patient to this immune over response is; inoculated populations, trauma, burns or long-term antibiotic and/or steroid use, as well as patients with indwelling catheters or those admitted comatose.

Mortality results from specific major organ failure, and no organ is immune from the ravages of the inflammatory excesses. The brain, the gut, and all organs/systems are affected.

Looking at the circulatory system, there is loss of auto regulation as vasoactive mediators (specifically nitric oxide, bradykinin and histamine) causes vasodilatation and an increase in microvascular permeability. There is impaired secretion of vasopressin that should counteract the effect of nitric oxide. Regional hypoperfusion occurs as blood is maldistributed in the microcirculation. This in turn affects arterial vascular tone and diminishes venous return from the vasodilatation of the microcirculation, and the release of myocardial depressant proteins results in hypotension (low blood pressure). Tachycardia (fast heart rate) occurs and or bradycardia can be a problem as the heart tries to compensate.

In the pulmonary system, endothelial cell injury leads to disturbed capillary blood flow and enhanced microvascular permeability, resulting in interstitial and alveolar edema. Neutrophil entrapment within the pulmonary microcirculation starts and exacerbates alveolar capillary membrane injury, resulting in acute respiratory distress syndrome (ARDS).

Liver dysfunction occurs when the reticuloendothelial filtering ability of this organ is unable to clear the offending foreign agents and their by products. These by products spill over into the systemic circulation, further aggravating the inflammatory response. The liver goes into a shock state; there is liver enzyme elevation, bilirubin buildup, coagulation defects and failure to excrete toxins, particularly ammonia, leading to worsening encephalopathy, (altered mentation, confusion, coma).

The renal system response is manifested by tubular necrosis (ATN). The kidneys are severely dependent on blood flow, and if at any time this blood flow is interrupted with hypotension/hypoperfusion, (low blood pressure) there is renal vasoconstriction, release of cytokines, and activation of neutrophils by endotoxins and other peptides, contributing to renal injury and failure.

In the gastrointestinal system, hypoperfusion may cause intestinal ischemia or infarction, ileus, pancreatitis, cholecystitis, and bowel perforation. The stress of the disease process may also lead to gastrointestinal bleeding. There is intolerance to enteral feedings resulting in diarrhea and malnutrition. Massive antibiotic therapy may also stimulate diarrhea, exacerbating fluid and electrolyte imbalances.
The endocrine system is not exempt from the foreign agent insult. There is impaired glucose regulation with hyperglycemia and insulin resistance. There is impaired response to ACTH (adrenocorticotropic hormone) stimulation. This in turn diminishes the release of cortisol, an enzyme that assists in glucose metabolism in times of stress, making glucose less available as an energy source.

Subclinical coagulopathy also occurs (clotting problems). Thrombocytopenia (low platelets) is prevalent, as are leucocytosis (high white blood cells) and leucopenia (low white blood cells). There might be evidence of DIC (disseminated intravascular coagulation) if the partial thromboplastin, activated partial thromboplastin time, (blood tests to determine how long it takes for the blood to clot) increased levels of fibrin split products, and increased levels of D-dimer (test to check for deep vein thrombosis, blood clots lung/brain) become evident.

Oxygen therapy must be initiated to deliver oxygen to tissues via fluid replacement therapy, vasoactive and inotropic agents, (to treat low blood pressure) and mechanical ventilation may be required. (to treat low
Metabolic support includes early nutrition either through the gut or intravenously with TPN. Lastly, immunologic support must include selected and targeted antibiotic therapy, timely surgical intervention and limiting breaches of mucosal defenses. Treatment could be implemented with the use of anti inflammation cytokines. Timing is essential.

My question is in the cases where babies, infants, children present with signs and symptoms after vaccination, are they rushed to the hospital and do the physicians think about collecting blood to measure cytokines? MRI of the brain? Liver enzymes evaluated? Chest X-ray to check respiratory status? Colonoscopy, and other bowel diagnostic procedures?  Is ‘leaky gut syndrome’ considered? Translocation considered? Collect a ‘blue tube’ and place on ice to measure; bacterial DNA by PCR method? Screen samples of hair, urine, bone, for heavy metals, mercury, aluminum, etc.

Are any of these parameters evaluated/measured when assessing whether the vaccine was associated with or is causal for the symptoms?

It would seem prudent for the medical and scientific fields to consider these aspects and begin evaluating these entities because the clinical care of persons presenting with these symptoms are not only exhibited by those claiming vaccine injury, but by all sorts of patients who present with sepsis. A diagnosis; if treated immediately, results in up to a 22% – 50% mortality rate. If treatment/intervention delayed for 24 -48 hours the mortality rate rises to 100%. Sepsis is ranked the 10th leading cause of death in the USA, killing 750,000 and costing $16-$17billion a year. Even with all our research those statistics have remained unchanged.

*The main emphasis should be on rapid identification and intervention. Cutting edge research and new studies support that if treated within the first four hours of onset with ‘anti cytokines’ the lethal outcome can be prevented. The devastating life changing disabilities could be averted.

The era of HIV/AIDS led to many breakthroughs, resulted in further understanding of our immune system, and led to the field of transplantation developing many more anti rejection drugs. Studying, evaluating patients who present with vaccine adverse events has the potential to lead to not only discovery of a definitive cause of the increasing phenomenon, but also has the potential to help us better understand the immune system and cytokine storm/sepsis phenomenon.

Disclaimer: This information is copyright protected and intended for educational purposes, not meant to diagnose nor prescribe. As a parent if my child or family member presented with symptoms, I would rush them to the hospital ER immediately and begin asking the treating physicians to check all the parameters indicative of cytokine storm. The life you save may be that of your loved one and may lead to saving other innocent victims as well as save healthcare dollars and resources.

In addition, the vaccines create chaos in the immune system, altering the apoptosis (programmed cell death) mechanism, creating aberrancy in the mRNA and dendritic cell mechanisms.

Studies are finding that kids with autism have elevated inflammatory cytokines and babies born with autism have mothers with inflammatory cytokines, however, the studies fail to mention the inoculation status of the subjects.  Vaccines stimulate inflammatory cytokines, therefore, is it safe to administer vaccines during pregnancy?

We are reading and hearing about autism having a genetic basis and/or the role of mitochondria function or malfunction; studies are finding how the mercury in vaccines is altering the mitochondria mechanism

Some more recent and promising interventional research is looking at Slit/Robo Pathway and Vascular Stabilization. (#6)  Evidence is growing that these common endpoints are the direct result of the response of the vascular endothelium to cytokine storm, the massive release of cytokines as part of the innate immune system response to infection. Slit proteins, acting through their Robo (Roundabout) receptors, have a well known role in axonal guidance during neural development.

The laboratory of Dr. Dean Li, Navigen’s Chief Scientific Officer and co-founder, identified an endothelial-specific Robo, Robo4, and determined its role in maintaining vascular integrity. One of the first effects of angiogenic factors and inflammatory cytokines on endothelial cells is to trigger the dissociation of cell-cell contacts, leading to increased vascular permeability. Dr. Li and colleagues have illustrated in in-vitro models that activation of Robo4 receptors with Slit2N can substantially reduce vascular permeability induced by lipopolysaccharide (LPS), tumor necrosis factor-a(TNF-a), and interleukin-1ß (IL-1ß), all important mediators of inflammation.

Because the Slit-Robo4 pathway tempers the effects of such a broad range of angiogenic and inflammatory cytokines on the endothelium, Dr. Li and colleagues examined whether Slit2N promotes vascular stability by directly enhancing the mechanisms responsible for cell-cell interactions. In the endothelium, critical stabilizing interactions are mediated by the adherens junction protein, vascular endothelial cadherin (VE-cadherin). IL-1ß reduced VE-cadherin levels at the cell surface and Slit2N negated this effect. Further, IL-1ß stimulation decreased p120-catenin (a critical stabilizer of VE-cadherin) at the cell surface and Slit2N reversed this effect as well.

The Slit-Robo4 pathway offers a potential means of controlling the endothelial response to cytokine storm, thereby limiting breakdown of the vascular endothelium. Indeed, Dr. Li and colleagues have demonstrated convincing evidence of efficacy of Slit2N in mouse models of acute lung injury (ALI), influenza and sepsis. In these studies, Slit2N reduced vascular leak as measured by extravasation of Evans blue dye from the vascular space into organs such as lung (ALI, influenza) and spleen and liver (sepsis). Importantly, Slit2N also significantly reduced mortality in animal models of influenza and sepsis. These findings have been the subject of recent expert commentaries in high profile scientific journals.

Sources:
http://www.autismcalciumchannelopathy.com/Abnormal_biomed_findings.html
http://www.ncbi.nlm.nih.gov/pubmed/21623535
http://www.ncbi.nlm.nih.gov/pubmed/16512356
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991432/
http://www.autismcalciumchannelopathy.com/Abnormal_biomed_findings.html
http://www.ncbi.nlm.nih.gov/pubmed/20833247
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170586/
http://nursing.advanceweb.com/Continuing-Education/CE-Articles/Multiple-Organ-Dysfunction-Syndrome.aspx
http://www.ei-resource.org/articles/leaky-gut-syndrome-articles/leaky-gut-syndrome:-the-systemic-consequences-of-faulty-digestion/
http://en.wikipedia.org/wiki/Cytokine_stormhttp://navigenpharma.com/interests
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875996/
http://stm.sciencemag.org/content/2/23/23ra19.abstract
http://biotuesdays.com/2011/03/22/2011-could-be-transition-year-for-cytosorbents/

RESOURCES:
Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien C-B, Wu JY, Urness LD and Li DY.
Robo4 Is a Vascular-Specific Receptor that Inhibits Endothelial Migration (2003). Developmental Biology 261: 251-67.

Jones CA, London NR, Chen H, Park KW, Sauvaget D, Stockton RA, Wythe JD, Suh W, Larrieu-Lahargue F, Mukouyama Y-s, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg MH, Gerhardt H, Zhang K, and Li DY.
Robo Stabilizes the Vascular Network by Inhibiting Pathologic Angiogenesis and Endothelial Hyperpermeability (2008).

Nature Medicine 14:448-53.
Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg MH, and Li DY.
Slit2-Robo4 Signaling Promotes Vascular Stability by Blocking Arf6 Activity (2009). Nature Cell Biology X: 1325-33.

London NR, Zhu W, Bozza FA, Smith MCP, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, and Li DY. Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza (2010). Science Translational Medicine 2:23ra19.

Lee WL and Slutsky AS. Sepsis and Endothelial Permeability (2010). New England Journal of Medicine 363:689-91.
Goldenberg NM, Steinberg BE, Slutsky AS, and Lee WL. Broken Barriers: A New Take on Sepsis Pathogenesis (2011). Science Translational Medicine 3:88ps25

End of specified copyright section.

2011 could be transition year for CytoSorbents
http://biotuesdays.com/2011/03/22/2011-could-be-transition-year-for-cytosorbents/​

Vaccine Adjuvants Review, 2011
http://www.invivogen.com/review-vaccine-adjuvants

Chapter 21:  Blood Vessels and Circulation
http://www.as.miami.edu/chemistry/2086/Chapter_21/NEW-Chap21_class_part1.htm

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SEPSIS
Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

Abstract

The innate immune system provides a first line of defense against invading pathogens by releasing multiple inflammatory cytokines, such as interleukin-1β and tumor necrosis factor–α, which directly combat the infectious agent and recruit additional immune responses. This exuberant cytokine release paradoxically injures the host by triggering leakage from capillaries, tissue edema, organ failure, and shock. Current medical therapies target individual pathogens with antimicrobial agents or directly either blunt or boost the host’s immune system. We explored a third approach: activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host’s response to the pathogen-induced cytokine storm. This approach reduced vascular permeability in the lung and other organs and increased survival in animal models of bacterial endotoxin exposure, polymicrobial sepsis, and H5N1 influenza. Thus, enhancing the resilience of the host vascular system to the host’s innate immune response may provide a therapeutic strategy for treating multiple infectious agents.

http://stm.sciencemag.org/content/2/23/23ra19.abstract​​

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Am J Emerg Med. 2008 Jul;26(6):711-5. doi: 10.1016/j.ajem.2007.10.031.
The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome.
Wang H, Ma S.

Abstract
Multiple organ dysfunction syndrome (MODS) is a major cause of morbidity and mortality in intensive care units. It is being encountered frequently in critically ill patients owing to advancements in organ-specific supportive technologies to survive the acute phase of severe sepsis and shock. It is now believed that MODS is the result of an inappropriate generalized inflammatory response of the host to a variety of acute insults. The pathologic mechanisms of MODS were reviewed, and factors determining the sequence and severity of organ dysfunction were discussed in depth. In the early phase of MODS, circulating cytokines cause universal endothelium injury in organs. In the later phase of MODS, overexpression of inflammatory mediators in the interstitial space of various organs is considered a main mechanism of parenchyma injury. The difference in constitutive expression and the upregulation of adhesion molecules in vascular beds and the density and potency of intrinsic inflammatory cells in different organs are the key factors determining the sequence and severity of organ dysfunction. By activating the intrinsic inflammatory cell in a distant organ, organ dysfunctions are linked in a positive feedback loop through circulating inflammatory mediators. Antagonists targeted at adhesion molecules may alleviate the severity of endothelial damage. And nonsteroidial anti-inflammatory drugs or steroids administered judiciously in the early phase of MODS may retard the progress of multiple organ failure.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294426/#B145

Cytokine storm
http://en.wikipedia.org/wiki/Cytokine_storm

GMO-DNA Vaccines And Cytokine Storms
By Richard Brown
6-22-11

Of particular note for anyone concerned about autism are parental claims that the vaccines led immediately to intense reactions in the children – screaming, severe diarrhea, seizures, etc.

Work by Russell Blaylock, a neurosurgeon investigating vaccination damage, points to cytokine reactivity as the inherent danger in all vaccines and the responses he lists dovetail with autism (and other disorders).

“The flu virus is supposed to cause a “cytokine storm,” and this inflammatory overreaction is what causes the damage, not the virus itself. This is interesting because all vaccines also cause a cytokine storm, one that can last for decades. This is why vaccines are linked to sudden death, joint pains, depression, weakness and fatigue, mental cloudiness, seizures, neurological disorders, and autoimmune diseases. (No one seems to be concerned about vaccine-caused cytokine storms, which are, in fact, immunoexcitotoxicity.)”

And yet developers of GMO-DNA vaccines applaud as a special advantage, that GMO-DNA vaccines induce large cytokine reactions.

Read more:
http://rense.com/general94/gmodna.htm

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Brain Behav Immun. 2011 Jan;25(1):40-5. doi: 10.1016/j.bbi.2010.08.003. Epub 2010 Aug 10.
Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome.
Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J.

Abstract
Autism spectrum disorders (ASD) are characterized by impairment in social interactions, communication deficits, and restricted repetitive interests and behaviors. A potential role for immune dysfunction has been suggested in ASD. To test this hypothesis, we investigated evidence of differential cytokine release in plasma samples obtained from 2 to 5 year-old children with ASD compared with age-matched typically developing (TD) children and children with developmental disabilities other than autism (DD). Participants were recruited as part of the population based case-control CHARGE (Childhood Autism Risks from Genetics and Environment) study and included: 97 participants with a confirmed diagnosis of ASD using standard assessments (DSM IV criteria and ADOS, ADI-R), 87 confirmed TD controls, and 39 confirmed DD controls. Plasma was isolated and cytokine production was assessed by multiplex Luminex™ analysis. Observations indicate significant increases in plasma levels of a number of cytokines, including IL-1β, IL-6, IL-8 and IL-12p40 in the ASD group compared with TD controls (p<0.04). Moreover, when the ASD group was separated based on the onset of symptoms, it was noted that the increased cytokine levels were predominantly in children who had a regressive form of ASD. In addition, increasing cytokine levels were associated with more impaired communication and aberrant behaviors. In conclusion, using larger number of participants than previous studies, we report significantly shifted cytokine profiles in ASD. These findings suggest that ongoing inflammatory responses may be linked to disturbances in behavior and require confirmation in larger replication studies. The characterization of immunological parameters in ASD has important implications for diagnosis, and should be considered when designing therapeutic strategies to treat core symptoms and behavioral impairments of ASD.

http://www.ncbi.nlm.nih.gov/pubmed/20705131

The immune response in autism: a new frontier for autism research

CYTOKINES IN AUTISM

Abstract

Autism spectrum disorders (ASD) are part of a broad spectrum of neurodevelopmental disorders known as pervasive developmental disorders, which occur in childhood. They are characterized by impairments in social interaction, verbal and nonverbal communication and the presence of restricted and repetitive stereotyped behaviors. At the present time, the etiology of ASD is largely unknown, but genetic, environmental, immunological, and neurological factors are thought to play a role in the development of ASD. Recently, increasing research has focused on the connections between the immune system and the nervous system, including its possible role in the development of ASD. These neuroimmune interactions begin early during embryogenesis and persist throughout an individual’s lifetime, with successful neurodevelopment contingent upon a normal balanced immune response. Immune aberrations consistent with a dysregulated immune response, which so far, have been reported in autistic children, include abnormal or skewed T helper cell type 1 (TH1)/TH2 cytokine profiles, decreased lymphocyte numbers, decreased T cell mitogen response, and the imbalance of serum immunoglobulin levels. In addition, autism has been linked with autoimmunity and an association with immune-based genes including human leukocyte antigen (HLA)-DRB1 and complement C4 alleles described. There is potential that such aberrant immune activity during vulnerable and critical periods of neurodevelopment could participate in the generation of neurological dysfunction characteristic of ASD. This review will examine the status of the research linking the immune response with ASD.

http://www.jleukbio.org/content/80/1/1.long#sec-4

Synergistic effects of toxic metals (mercury, lead, aluminum) are extreme

Autism has increased in the U.S. more than 10 fold in the last decade. According to the Florida Dept. of Education, the numbers increased from approx. 300 to over 4000 during this time period. There have likewise been large increases in the number of children with ADHD and other developmental conditions, according to the National Academy of Sciences and other sources. A major factor in this appears to be the large increase in vaccinations given to infants.

Source:
http://www.flcv.com/hgsynerg.html
http://www.healthandenvironment.org/articles/doc/53
https://ourhealthandenvironment.wordpress.com/tag/vaccines/

Empirical Data Confirm Autism Symptoms Related to Aluminum and Use of Acetaminophen, (Tylenol)
http://www.mdpi.com/1099-4300/14/11/2227

Ann Clin Psychiatry. 2009 Jul-Sep;21(3):148-61.
Phenotypic expression of autoimmune autistic disorder (AAD): a major subset of autism.
Singh VK.

Abstract

BACKGROUND:
Autism causes incapacitating neurologic problems in children that last a lifetime. The author of this article previously hypothesized that autism may be caused by autoimmunity to the brain, possibly triggered by a viral infection. This article is a summary of laboratory findings to date plus new data in support of an autoimmune pathogenesis for autism.

METHODS:
Autoimmune markers were analyzed in the sera of autistic and normal children, but the cerebrospinal fluid (CSF) of some autistic children was also analyzed. Laboratory procedures included enzyme-linked immunosorbent assay and protein immunoblotting assay.

RESULTS:
Autoimmunity was demonstrated by the presence of brain autoantibodies, abnormal viral serology, brain and viral antibodies in CSF, a positive correlation between brain autoantibodies and viral serology, elevated levels of proinflammatory cytokines and acute-phase reactants, and a positive response to immunotherapy. Many autistic children harbored brain myelin basic protein autoantibodies and elevated levels of antibodies to measles virus and measles-mumps-rubella (MMR) vaccine. Measles might be etiologically linked to autism because measles and MMR antibodies (a viral marker) correlated positively to brain autoantibodies (an autoimmune marker)–salient features that characterize autoimmune pathology in autism. Autistic children also showed elevated levels of acute-phase reactants–a marker of systemic inflammation.

CONCLUSIONS:
The scientific evidence is quite credible for our autoimmune hypothesis, leading to the identification of autoimmune autistic disorder (AAD) as a major subset of autism. AAD can be identified by immune tests to determine immune problems before administering immunotherapy. The author has advanced a speculative neuroautoimmune (NAI) model for autism, in which virus-induced autoimmunity is a key player. The latter should be targeted by immunotherapy to help children with autism.

http://www.aacp.com/pdf%2F2103%2F2103ACP_Research1.pdf
http://www.vacinfo.org/VJ.ACP2009.pdf
http://www.ncbi.nlm.nih.gov/pubmed/19758536

How Vaccines Dysregulate The Immune System 
http://gdsajj.wordpress.com/2011/08/05/how-vaccines-dysregulate-the-immune-system/

Vaccinations Cause Chronic Immune System Dysregulation
http://www.liveto110.com/vaccinations-cause-chronic-immune-system-dysregulation/

The Antibody Deception, (a good article on the subject matter of understanding the issue of vaccine effectiveness, and in regard to showing and proving actual vaccine effectiveness)
http://www.activistpost.com/2014/01/the-antibody-deception.html

An Immune Disorder at the Root of Autism

So here’s the short of it: At least a subset of autism — perhaps one-third, and very likely more — looks like a type of inflammatory disease. And it begins in the womb. [No it does NOT, and that is not necessarily true, unless the mother has taken a Thimerosal containing flu vaccine, or such as an aluminum adjuvant containing DTaP vaccine. Much of this dysregulation can clearly happen after birth, and of course infants are vaccinated, from birth.]

It starts with what scientists call immune dysregulation. Ideally, your immune system should operate like an enlightened action hero, meting out inflammation precisely, accurately and with deadly force when necessary, but then quickly returning to a Zen-like calm. Doing so requires an optimal balance of pro- and anti-inflammatory muscle.

In autistic individuals, the immune system fails at this balancing act. Inflammatory signals dominate. Anti-inflammatory ones are inadequate. A state of chronic activation prevails. And the more skewed toward inflammation, the more acute the autistic symptoms.

Nowhere are the consequences of this dysregulation more evident than in the autistic brain. Spidery cells that help maintain neurons — called astroglia and microglia — are enlarged from chronic activation. Pro-inflammatory signaling molecules abound. Genes involved in inflammation are switched on.

These findings are important for many reasons, but perhaps the most noteworthy is that they provide evidence of an abnormal, continuing biological process. That means that there is finally a therapeutic target for a disorder defined by behavioral criteria like social impairments, difficulty communicating and repetitive behaviors.

http://www.nytimes.com/2012/08/26/opinion/sunday/immune-disorders-and-autism.html/?pagewanted=all&_r=0

A Mouse Model for the Immune Dysregulation Subtype of Autism, (And they would still claim to that there is no way vaccines have and can cause autism? That conclusion is of course clearly preposterous.)
http://tacanowblog.com/2012/07/23/a-mouse-model-for-the-immune-dysregulation-subtype-of-autism/

Vaccines and Autism, ADHD and Asthma
Immunizations and the Immunocompromised

“Yet, no doctor is trained to look for this type of immunodeficiency and/or the kind of immune dysregulation that multiple vaccine can cause; which lead to so called inflammatory syndromes and resulting overactivation of the brains microglia cells and resulting chronic levels of brain inflammation now ever more increasingly found in studies of those with autism. Vaccine aluminum adjuvants in several studies have been fund as well to in itself cause this stated inflammation.

http://www.epidemicanswers.org/vaccines-and-autism-adhd-and-asthma/

Immune Deficiencies

Antibodies (or Immunoglobins)

Concentrations of IL-12 and interferon gamma are much higher in the blood of children with autism than in normal children, indicating an immune activation, possibly due to adverse vaccine reactions. An optimal immune response to Candida infections necessitates a finely tuned balance of interferon gamma production; the dysregulation of the immune system, caused by IL-12-induced increases in gamma interferon, leads to increased Candida susceptibility in animals.

Read more:
http://www.greatplainslaboratory.com/home/eng/immunedeficiencies.asp

The immune response in autism: a new frontier for autism research

Immune aberrations consistent with a dysregulated immune response, which so far, have been reported in autistic children, include abnormal or skewed T helper cell type 1 (TH1)/TH2 cytokine profiles, decreased lymphocyte numbers, decreased T cell mitogen response, and the imbalance of serum immunoglobulin levels. In addition, autism has been linked with autoimmunity and an association with immune-based genes including human leukocyte antigen (HLA)-DRB1 and complement C4 alleles described.

Read more:
http://www.jleukbio.org/content/80/1/1.long

Study links vaccine induced immune overload to autism, diabetes, obesity

A new vaccine study published in Molecular and Genetic Medicine is bringing to the forefront the disturbing connection between the dramatic expansion in the quantity of routine childhood vaccines administered and a corresponding increase in inflammation-associated disorders.

Titled, “Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases,” the study argues that vaccine-induced immune overload is a driving factor in a number of rapidly accelerating childhood epidemics including:

Autism
Type 1 diabetes
Asthma
Food allergies
Many autoimmune diseases
Obesity
Type 2 diabetes
Non-alcoholic fatty liver disease (NAFL)
Metabolic disease.

http://www.sott.net/article/279911-Study-links-vaccine-induced-immune-overload-to-autism-diabetes-obesity

Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases

Abstract Background: Epidemics of type 1 diabetes had been linked to inflammation. Previous reports have suggested the prevalence of autism is increased in patients with type 1diabetes.

Methods: Medline and Google searches were performed in late 2010 to find a country where there was simulta-neous data on the incidence or prevalence of type 1 diabetes, type 2 diabetes and autism in multiple different races. The association between prevalence of autism in children and the incidence of type 1 diabetes or type 2 diabetes in children, when stratified by race, was studied.

Results: The prevalence of autism has a statistically significant positive association with the incidence of type 1 diabetes but has a statistically significant inverse association with type 2 diabetes.

Conclusion: This suggests that patients with autoimmune autism likely represent a large subset of patients with autism and that the etiology of the epidemic of autoimmune/inflammation mediated autism in children is likely to be related to the etiology of the simultaneous epidemic of type 1 diabetes in children.

http://www.omicsonline.com/open-access/vaccine-induced-immune-overload-and-the-resulting-epidemics-of-type-diabetes-and-metabolic-syndrome-1747-0862.S1-025.php?aid=24058

BMJ. Oct 23, 1999; 319(7217): 1133.
PMCID: PMC1116914
Association between type 1 diabetes and Hib vaccine
Causal relation is likely
J Barthelow Classen,
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1116914/

“Hib immunization contributed to an increased risk for H. influenzae type a meningitis through selection of circulating H. influenzae type a clones.” ” the incidence for H. influenzae type a meningitis increased 8-fold”
http://jid.oxfordjournals.org/content/187/1/109.full.pdf+html

Autoimmune Disorders Caused by Vaccines
http://healthimpactnews.com/2012/autoimmune-disorders-caused-by-vaccines/

Self-Organized Criticality Theory of Autoimmunity

Conclusions/Significance

Systemic autoimmunity appears to be the inevitable consequence of over-stimulating the host’s immune ‘system’ by repeated immunization with antigen, to the levels that surpass system’s self-organized criticality.

http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0008382

Metals and heavy metals do not belong in the human body, period. Not in tooth filings, nor in injected vaccines. 

Mercury Exposure Levels from Amalgam Dental Fillings; Documentation of Mechanisms by Which Mercury Causes over 30 Chronic Health Conditions; Results of Replacement of Amalgam Fillings; and Occupational Effects on Dental Staff, (597 references)
http://www.flcv.com/amalg6.html

DENTAL AMALGAM FILLINGS PAGE
http://www.flcv.com/indexa.html

—————————–

Do You Know How the Flu Virus Works?

The flu virus causes immune cells to produce cytokine molecules that increase inflammation. Normally this is controlled, but in extreme cases, a “cytokine storm” occurs. This can cause tissue and organ damage, and even death.

When you’re fighting the flu, you feel bad not because of the virus but rather because of the “cytokine storm.”

But get this: All vaccines trigger their own cytokine storms. And researchers now know that increased inflammation is at the heart of most illness and disease. Which means the vaccines themselves are hazardous to your health.

The solution is to avoid flu shots, and if you’ve had them in the past, to take nutrients that will strengthen your immune system and reduce inflammatory cytokine activity.

The following nutrients — fully detailed in your FREE REPORT — are your best course for defense and repair . . .

Vitamins C and E, plus carotenoids: See how a deficiency suppresses your immune system, a common problem among the elderly.

Vitamin D: See how five to 10 times the RDA will protect you against flu, weak bones, cancer, and more, but you must get the “right type.”

Curcumin and quercetin: Combining the two in my recommended dosages will calm a cytokine storm and prevent bodily damage!

Magnesium, selenium, and zinc: These can control inflammation and strengthen immunity, but see which types to use!
Resveratrol: See the type and dosage to prevent viral replication. It also protects your brain from damage!

Three little-known supplements that will increase immune-boosting glutathione in your cells, fight viral infection, and reduce inflammation!

Inflammatory foods to avoid that contain omega 6 oils, iron, sugar, mercury, and fluoride.

Read more:
http://w3.newsmax.com/blaylock/62b.cfm

Making Sense of the Cytokine Storm: a conceptual framework for understanding, diagnosing and treating hemophagocytic syndromes

SYNOPSIS
Cytokine Storm Syndromes (CSS) are a group of disorders representing a variety of inflammatory etiologies with the final common result of overwhelming systemic inflammation, hemodynamic instability, multiple organ dysfunction, and potentially death. The hemophagocytic syndromes hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) represent two clinically similar CSS with an unknown degree of pathoetiologic overlap. The clinical presentations of all CSS can be strikingly similar, creating diagnostic uncertainty. However, clinicians should avoid the temptation to treat all CSS equally, as their inciting inflammatory insults vary widely. Failure to identify and address this underlying trigger will result in delayed, inoptimal, or potentially harmful consequences. This review endeavors to place the hemophagocytic syndromes HLH and MAS within a conceptual model of CSS, and thus provide a logical framework for diagnosis and treatment of CSS of suspected rheumatic origin.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368378/

What is the Cytokine Storm?
http://www.wisegeek.org/what-is-the-cytokine-storm.htm
http://www.wisegeek.com/what-factors-affect-cytokine-production.htm
http://www.wisegeek.org/what-are-inflammatory-cytokines.htm

Part 3 of 3: An Interview About Vaccines with Helen V. Ratajczak, PhD

Q. 21. Can vaccines cause ‘cytokine storms’ (hypercytokinemia) in infants? Can you talk about that at length a little, as parents—and maybe some MDs and emergency room docs and nurses—aren’t aware of that type of adverse reaction to vaccines?

Yes, vaccines can and do cause hypercytokinemia, also known as cytokine storms (Ponce, 2008; Binstock, 2009). A cytokine storm results when the body’s immune system rages out of control, resulting in overwhelming inflammation, rapid organ failure, and death if not quickly diagnosed and treated (Children’s Hospital of Philadelphia, 2011). Immunostimulation may develop via modulation of pathways involved in immune system regulation. Binstock gives some side effects of various vaccines, taken from the CDC’s list of possible side effects from vaccines, which are given for individual vaccines. For DTaP: fever, swelling (for 1 to 7 days) of the entire limb in which the shot was given after the 4th or 5th dose of DTaP vaccine; fussiness; tiredness or poor appetite; vomiting; jerking or staring; non-stop crying for 3 or more hours; fever of >105 degrees Fahrenheit; long-term seizures, coma or lowered consciousness; permanent brain damage. For Hib: fever > 101 degrees Fahrenheit. For MMR: fever, seizure; temporary low platelet count (which can cause a bleeding disorder); temporary pain and stiffness in the joints, mostly in teenage or adult women; long-term seizures, coma, or lowered consciousness, permanent brain damage. For Vermicelli: Fever, mild rash, up to a month after vaccination. Binstock notes that the first dose of MMRV vaccine has been associated with rash and higher rates of fever than MMR and varicella vaccines given separately. Seizures caused by a fever are also reported more often after MMRV. In addition, usually occurring 5-12 days after the first dose, vaccines can induce seizure (jerking or staring), caused by fever and other serious problems (which are very rare) including severe brain reactions and low blood count.

Two manuscripts that describe means of ameliorating cytokine storms follow: The Children’s Hospital of Philadelphia (2011) conducted a study on clues to calming a cytokine storm. Included in those suffering from cytokine storm, children with juvenile arthritis and patients with lupus or Epstein-Barr virus infection may also suffer from macrophage activation syndrome (MAS). The study reports development of an animal model of MAS in mice, and differentiates MAS from hemophagocytic lymphohistiocytosis (HLH), which also causes a life-threatening cytokine storm in children. HLH is caused by a genetic mutation, but MAS is not. Inflammation from rheumatological diseases like systemic juvenile arthritis causes MAS by acting through immunological pathways. Two important molecules in the immune system control the severity of MAS: Interferon-gamma, which makes MAS more severe, and Interleukin-10, which has a protective effect.

Another study by Boukhvalova et al. (2006) describes a TLR4 agonist, monophosphoryl lipid A, which attenuates the cytokine storm associated with respiratory syncytial virus vaccine-enhanced disease.

Source for the article:
http://vactruth.com/2011/06/10/part-3-of-3-an-interview-about-vaccines-with-helen-v-ratajczak-phd/

Protect Yourself From Death By “Cytokine Storm” and Gross Criminal Negligence
http://preventdisease.com/news/09/111609_protect_yourself_cytokine_storm.shtml

Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus

Abstract
Human pandemic H1N1 2009 influenza virus rapidly infected millions worldwide and was associated with significant mortality. Antiviral drugs that inhibit influenza virus replication are the primary therapy used to diminish disease; however, there are two significant limitations to their effective use: (i) antiviral drugs exert selective pressure on the virus, resulting in the generation of more fit viral progeny that are resistant to treatment; and (ii) antiviral drugs do not directly inhibit immune-mediated pulmonary injury that is a significant component of disease. Here we show that dampening the host’s immune response against influenza virus using an immunomodulatory drug, AAL-R, provides significant protection from mortality (82%) over that of the neuraminidase inhibitor oseltamivir alone (50%). AAL-R combined with oseltamivir provided maximum protection against a lethal challenge of influenza virus (96%). Mechanistically, AAL-R inhibits cellular and cytokine/chemokine responses to limit immunopathologic damage, while maintaining host control of virus replication. With cytokine storm playing a role in the pathogenesis of a wide assortment of viral, bacterial, and immunologic diseases, a therapeutic approach using sphingosine analogs is of particular interest.

http://www.pnas.org/content/108/29/12018.abstract

Nature. 2010 Mar 4;464(7285):104-7. doi: 10.1038/nature08780.
Circulating mitochondrial DAMPs cause inflammatory responses to injury.
Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ.

Abstract
Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogen-associated molecular patterns (PAMPs) activate innate immunocytes through pattern recognition receptors. Similarly, cellular injury can release endogenous ‘damage’-associated molecular patterns (DAMPs) that activate innate immunity. Mitochondria are evolutionary endosymbionts that were derived from bacteria and so might bear bacterial molecular motifs. Here we show that injury releases mitochondrial DAMPs (MTDs) into the circulation with functionally important immune consequences. MTDs include formyl peptides and mitochondrial DNA. These activate human polymorphonuclear neutrophils (PMNs) through formyl peptide receptor-1 and Toll-like receptor (TLR) 9, respectively. MTDs promote PMN Ca(2+) flux and phosphorylation of mitogen-activated protein (MAP) kinases, thus leading to PMN migration and degranulation in vitro and in vivo. Circulating MTDs can elicit neutrophil-mediated organ injury. Cellular disruption by trauma releases mitochondrial DAMPs with evolutionarily conserved similarities to bacterial PAMPs into the circulation. These signal through innate immune pathways identical to those activated in sepsis to create a sepsis-like state. The release of such mitochondrial ‘enemies within’ by cellular injury is a key link between trauma, inflammation and SIRS.

http://www.ncbi.nlm.nih.gov/pubmed/20203610

Study of deadly cytokine storm could lead to new flu drugs
http://www.utsandiego.com/news/2011/sep/15/study-deadly-cytokine-storm-could-lead-new-flu-dru/

Aluminum Used in Vaccines: Dr. Mercola’s Interview with Dr. David Ayoub (Part 1 of 5)
http://www.youtube.com/watch?list=PLA4C0EE7C6DCF3713&v=CXWBxxVk_h0

Adventitious Agents and Vaccines
Philip R. Krause
Food and Drug Administration, Bethesda, Maryland, USA
http://wwwnc.cdc.gov/eid/article/7/7/pdfs/01-7735.pdf

VRM: Primary Reasons Not To Get The Flu Shot

‘Production of viral vaccines (ie. Flu Vaccine) generally involves inoculation of a cell substrate with a vaccine seed and purification of bulk product from these cells after a sufficient time for replication of the virus or production of vaccine proteins. Other raw materials (e.g., tissue culture reagents, stabilizers) may be added to the product at various stages of production. Thus, adventitious agents could theoretically enter a viral vaccine through any of these ingredients.‘ Philip R. Krause, FDA
Note: ‘Adventitious agents (mutable hybrid viruses/cross-contamination/cancer causing strains) could theoretically enter a viral vaccine through any of these ingredients (cell substrates, vaccine seed, tissue culture reagents, stabilizers).’

http://vaccineresistancemovement.org/?p=12642

Cytokine responses in patients with mild or severe influenza A(H1N1)pdm09

Conclusions
A number of cytokines were found to be substantially elevated in patients with severe influenza A(H1N1)pdm09 virus infection. This supports and extends other published work suggesting a role for proinflammatory cytokines in influenza-induced lung pathology. Interestingly, EGF was significantly lower in patients with severe infection suggesting it is actively suppressed. As EGF has a role in role in cell proliferation and tissue repair, it may protect the lung from host or virus mediated damage.

http://www.sciencedirect.com/science/article/pii/S1386653213001911

Into the Eye of the Cytokine Storm

SUMMARY

Summary: The cytokine storm has captured the attention of the public and the scientific community alike, and while the general notion of an excessive or uncontrolled release of proinflammatory cytokines is well known, the concept of a cytokine storm and the biological consequences of cytokine overproduction are not clearly defined. Cytokine storms are associated with a wide variety of infectious and noninfectious diseases. The term was popularized largely in the context of avian H5N1 influenza virus infection, bringing the term into popular media. In this review, we focus on the cytokine storm in the context of virus infection, and we highlight how high-throughput genomic methods are revealing the importance of the kinetics of cytokine gene expression and the remarkable degree of redundancy and overlap in cytokine signaling. We also address evidence for and against the role of the cytokine storm in the pathology of clinical and infectious disease and discuss why it has been so difficult to use knowledge of the cytokine storm and immunomodulatory therapies to improve the clinical outcomes for patients with severe acute infections.

http://mmbr.asm.org/content/76/1/16.full
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294426/

J Immunotoxicol. 2008 Jan;5(1):33-41. doi: 10.1080/15476910801897920.
Adverse consequences of immunostimulation.
Ponce R.

Abstract
The therapeutic uses of immunostimulatory agents are generally in the treatments of infections or cancer. The traditional example of vaccination is one form of immunostimulation used in the prevention of pathogenic infections or cancer (e.g., human papillomavirus vaccine). Recombinant cytokines are increasingly used to stimulate immune system function. For example, interferon-alpha (IFNalpha) and interleukin (IL)-2 have been used to treat chronic hepatitis C virus infection and metastatic melanoma, respectively. In contrast, monoclonal antibodies are used to target malignant cells for elimination via antibody-dependent cytotoxicity mechanisms or apoptosis, including the anti-CD20 monoclonal antibody rituximab and the anti-CD56 monoclonal antibody alemtuzumab used in the treatment of B-cell malignancies, and the anti-erb2 receptor antibody trastuzumab used in the treatment of breast cancer. Finally, immunostimulation may develop via modulation of pathways involved in immune system regulation. For example, the anti-CD28 monoclonal antibody TGN1412 was developed as an agonist of regulatory T-cells for treatment of T-cell-mediated chronic inflammatory diseases or leukemias. A panel was convened to discuss potential toxicities associated with immunostimulation. At the Immunotoxicology IV meeting in 2006, a panel, moderated by Dr. Robert House (Dynport Vaccine Co., Frederick, MD), included Drs. Gary Burleson (Burleson Research Technologies, Inc., Raleigh, NC), Kenneth Hastings (US FDA, Center for Drug Evaluation and Research [CDER], Rockville, MD), Barbara Mounho (Amgen, Thousand Oaks, CA), Rafael Ponce (ZymoGenetics, Inc., Seattle, WA), Mark Wing (Huntington Life Sciences, Cambridgeshire, United Kingdom), Lauren Black (Navigators Consulting, Sparks, NV) and Anne Pilaro (US FDA, CDER, Rockville, MD). This paper reviews the major identified toxicities associated with immunostimulation, including the acute phase response, cell and tissue abnormalities/injury, cytokine release/cytokine storm, tumor lysis syndrome, vascular leak, and autoimmunity that were discussed by this panel.

http://www.ncbi.nlm.nih.gov/pubmed/18382856

Vaccinations, cytokine storms, and autism
http://www.cafemom.com/journals/read/1501732/Vaccinations_Cytokine_Storms_and_Autism

4 Things You Didn’t Know About Vaccines
http://gnowfglins.com/2013/02/08/4-things-you-didnt-know-about-vaccines/#

Problems with Today’s Vaccines
http://articles.mercola.com/sites/articles/archive/2011/11/03/right-vaccine-dosage-for-babies.aspx​

Vaccines & Overdosed Babies
http://www.youtube.com/watch?v=s49xpHl3hWI

You will never look at vaccinated children the same!- Shedding Viruses
http://www.youtube.com/watch?v=VKSeiAs_A4w

Barbs Health Blog
http://barbshealthblog.blogspot.com/

The Central Mechanism By Which Vaccines Induce Autism – Dr. Russell Blaylock Lecture
http://www.youtube.com/watch?feature=player_embedded&v=uS0ioiB0_oY

Drugs and Vaccines Kill – Toxins Do Not Heal!
http://drrimatruthreports.com/5-big-lies-drugs-vaccine/

Dr Andrew Moulden (a few good videos)
http://www.youtube.com/watch?feature=player_embedded&v=X4l4WyQuKhY
http://www.youtube.com/watch?feature=player_embedded&v=hS080izL3zQ
http://www.youtube.com/watch?feature=player_embedded&v=RG2BHffHjZE

VACCINATIONS: PART I – MEDICAL RESEARCH ON SIDS AND EPIDEMICS 
http://www.consumerhealth.org/articles/display.cfm?ID=19990705002005

This is one of the links you can find. Below, I found that of interest as well.
http://barbshealthblog.blogspot.com/2013/11/redacted-vaccine-death-forensics-report.html

Joyce Riley Interviews Dr. Andrew Moulden
http://www.thepowerhour.com/news3/dr_andrew_moulden_transcript.htm

Serious Case Review
Executive Summary
In respect of Baby M (This is the standard medical side finding, and as always, with not a clue about the actual vaccine connection)

INTRODUCTION

CIRCUMSTANCES OF CHILD M’S DEATH

1. Baby M was born in August 2007, the second child of B (mother) and the
first of C (father). In late January 2008 an emergency ambulance was
called to the family home and Baby M was found to be in cardiac arrest.
Baby M was transferred to hospital where Baby M was pronounced dead.

2. The pathologist’s report of the subsequent post mortem examination
concluded that on the balance of probability, the cause of death was
pneumonia. At the inquest, held in December 2008, the Coroner’s verdict
confirmed this, and was at pains to assure the parents that they could
not have known that their child was suffering from pneumonia and thus
could not have done anything about it.

3. Baby M and older half-sibling, Child D were the subjects of a child
protection plan at the time of Baby M’s death. Baby M and family were
receiving multi-agency support due to increasing concerns about the
children’s welfare since the early months of D’s life.

Read more:
http://www.lscb.org.uk/wp-content/uploads/Baby-M.pdf

I found these studies related and of interest.

http://www.ncbi.nlm.nih.gov/pubmed/9807829
http://www.pnas.org/content/88/5/1913.full.pdf
http://www.pnas.org/content/88/11/4656.full.pdf

Interestingly they are pulling cadmium out of some of these vaccine injured children with DMSA chelation. Oddly I did not find the interaction connection between cadmium and glutathione deficiency, in human pathology, but plant pathology. Pretty odd, but what if?

A Cadmium-Sensitive, Glutathione-Deficient Mutant of A ra bidopsis tha lia na’
http://www.plantphysiol.org/content/107/4/1067.full.pdf

Vaccine Production With – Human Diploid Cells (aborted fetal cell tissue, lots of science, here)
http://www.vacfacts.info/vaccine-production-with—human-diploid-cells-aborted-fetal-cell—tissue.html

——–

How Vaccines Can Induce Autism
http://essentialsurvival.org/how-vaccines-can-induce-autism/

Vaccines — Panacea or Pandora’s Box?

I learned that vaccines increase the chances of autoimmune illness, cancer, and many other chronic illnesses common today.

Vaccines are an unnatural way for our bodies to be exposed to pathogens and it shouldn’t surprise us to learn that they actually alter the way our immune systems function. Vaccines shift the immune system away from cellular immunity, which occurs when we are exposed to a disease, toward humoral immunity where antibodies are produced in response to the injected virus or bacteria (ie antigens).

The problem is that we need the T cells and Natural Killer cells from cellular immunity, and the vaccines actually suppress that part of our immune system.  Impaired cellular immunity makes a person susceptible to a whole host of disease including cancer, autoimmune illness, allergies, eczema, and more.

The other way in which vaccines can harm the immune system is through over-stimulation. Stimulate the immune system artificially one too many times, and it could be the proverbial straw that breaks the camel’s back!  Believe me — you do NOT want this to happen to you or someone you love.

http://essentialsurvival.org/problems-with-vaccines/

Endothelial dysfunction
http://en.wikipedia.org/wiki/Endothelial_dysfunction

J Am Soc Nephrol. 2004 Aug;15(8):1983-92.
Endothelial dysfunction.
Endemann DH, Schiffrin EL.
http://www.ncbi.nlm.nih.gov/pubmed/15284284

Circulating Markers of Endothelial Function

A broader appreciation of the numerous functions of the endothelium can be obtained by study of the levels of molecules of endothelial origin in circulating blood. These include direct products of endothelial cells that change when the endothelium is activated, such as measures of NO biology, inflammatory cytokines, adhesion molecules, regulators of thrombosis, as well as markers of endothelial damage and repair. Many of these circulating markers are difficult and expensive to measure, and currently are only used in the clinical research setting. In this context, these measures can provide important information regarding mechanisms and severity of endothelial dysfunction in populations, and complement physiological tests of endothelial vascular control.61 As a result of biological and assay availability and variability, these factors currently have only a very limited role in the assessment of individual patients.

Circulating endothelial cells that detach in the context of endothelial activation and loss of integrity can be measured in the circulation by both flow cytometry and a combination of magnetic bead selection and fluorescent microscopy.73

http://circ.ahajournals.org/content/115/10/1285.full

Clin Lab. 2005;51(9-10):531-8.
Circulating endothelial cells: markers of vascular dysfunction.
Goon PK, Boos CJ, Lip GY.

Abstract
Circulating endothelial cells (CEC) have evolved as a novel method of assessing endothelial function. Rarely found in the peripheral blood of healthy individuals, CECs increase in a wide variety of conditions such as cardiovascular disease, cancer, infection and inflammatory states. Unlike immature endothelial progenitor cells (EPC), which are bone marrow derived, CECs are felt to represent the detachment of mature endothelial cells from the endothelial monolayer, as a result of endothelial insult. In this article we present an overview of CECs and their association with a broad spectrum of disease processes.

http://www.ncbi.nlm.nih.gov/pubmed/16285476?dopt=Abstract

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Aluminum: The Neurotoxin Far Worse than Mercury…
http://www.thelibertybeacon.com/?p=16598

Vaccine aluminum adjuvant causation of neuroglial activation and neuroinflammation in the brain of patients with autism.
http://www.vacfacts.info/vaccine-aluminum-adjuvant-causation-of-neuroglial-activation-and-neuroinflammation-in-the-brain-of-patients-with-autism.html

Vaccine Caused Ischemia/Hypoxia
http://www.vacfacts.info/vaccine-caused-ischemiahypoxia.html

Vaccination toxicity: The Zeta phase of MASS and “blood sludging”
http://www.vacfacts.info/vaccination-toxicity-the-zeta-phase-of-mass-and-ldquoblood-sludgingrdquo.html

SBS cases falsely acussed, Christina England 
http://parentsandcarersagainstinjustice.weebly.com/

The Vaccine Damage Science
http://www.vacfacts.info/the-vaccine-damage—science.html

Toxic Overload: Children Vaccinated To Extreme
http://www.thelibertybeacon.com/?p=16643

Vaccinations Cause Chronic Immune System Dysregulation
http://www.thelibertybeacon.com/?p=16251

There Is No Such Thing As a Safe Vaccine and There Never Will Be
http://wp.me/p2X3AR-47a

Vaccines Are Causing Mutations That May Jeopardize
The Health of Future Generations
http://www.thelibertybeacon.com/?p=16698

Forced Vaccination is Equivalent to Human Experimentation
and Subject to the Nuremberg Code
http://www.thelibertybeacon.com/?p=13171

Multiple Infant Vaccines Linked To Dramatically
Increased Mortality ~ By: Sayer Ji
Read article here: http://wp.me/p2X3AR-4dx

Vaccination During Pregnancy: Is It Safe?
http://wp.me/p2X3AR-4bT

Flu Shot Causes Polio-like Guillain-Barré Syndrome:Are Rates Higher Than the Government Admits?
http://wp.me/p2X3AR-4c1

Flu Vaccine Is the Most Dangerous Vaccine In the U. S. Based On Settled Cases For Injuries
http://wp.me/p2X3AR-49A

The Vaccine Mafia and Its Jury of Thugs: Your Rulers
Read this scathing critique here: http://wp.me/p2X3AR-47x

Are Vaccines Safe: Bracing Ourselves for More Sham Vaccine Studies
Read this very critical article here: http://wp.me/p2X3AR-43O

Vaccines? Researchers Now Pushing Vaccine for PTSD
http://wp.me/p2X3AR-3TR

The Hidden Connection Behind Viruses, Vaccines and Cancer

By: Dr. Tyson Perez

Mainstream medicine tells us that the hepatitis B virus (HBV) causes liver cancer which is why it is so necessary for US newborns to be vaccinated within hours of birth.  We are told that the human papillomavirus (HPV), which is supposedly so prevalent in our population, causes cervical cancer which is why there is such a push to vaccinate girls and boys in the US as early as 9 years old. Let’s not forget about Simian Virus 40 (SV40) which is known to have contaminated polio vaccines and is associated with a wide variety of human cancers.  Conventional wisdom tells us that viruses cause cancer.  But is this true? Let’s investigate the story further.

The first recorded cases of HBV infection occurred following the administration of the smallpox vaccine containing human lymph to shipyard workers in Germany in 1883. HBV is transmitted through contact with infected bodily fluids.  It is estimated that over 2 billion people worldwide have been infected and that approximately 350 million are chronic carriers.  Chronic HBV infection is believed to cause up to 80% of all hepatocellular carcinomas.  Sounds scary right?  But when you look deeper you find that, in the US, HBV is found predominantly in adults who are either I.V. drug users or engaging in high-risk sexual behavior.

Read more:
http://www.thelibertybeacon.com/2013/02/09/the-hidden-connection-behind-viruses-vaccines-and-cancer/

VRM: The Rise of Mutagenic Viruses
http://vaccineresistancemovement.org/?p=13124

Your Immune System, How It Works And How Vaccines Damage It

“Chronic illnesses are now so common, having a sick child seems to be the “new normal.”Children are supposed to be vibrant, healthy, free of disease.” – Janet Levatin MD, Pediatrician.

http://www.vaccineriskawareness.com/Your-Immune-System-How-It-Works-And-How-Vaccines-Damage-It

How Do Vaccines Work? Immune Mechanisms and Consequences (A basic decription of the differences between natural immunity, and that of so called vaccine derived immunity.
http://pathwaystofamilywellness.org/component/option,com_crossjoomlaarticlemanager/Itemid,375/aid,1369/view,crossjoomlaarticlemanager/

Vaccines Are Causing Mutations That May Jeopardize The Health of Future Generations

By: Dave Mihalovic

Vaccines are causing an unprecedented number of mutations creating superbugs and potent viruses and bacteria that may eventually threaten future generations and humanity itself. Evidence continues to mount from the scientific community who now admit that certain vaccines are in-fact causing both viral and bacterial mutations. Ironically, the same researchers assert that “better” vaccines are needed to offset the rise in persistent mutations.

Life-threatening pathogens are capable of evolving rapidly and developing genetic decoys that serve to disguise them from even the most powerful drugs. University of Oxford researcher Rory Bowden found that pathogens switch genetic material with other bacteria, but predominantly for the part of the genome responsible for making the cell coating, which is the area targeted by vaccines.

Former post-doctoral researcher of the Center for Infectious Disease Dynamics, Grainne Long found that vaccination led to a 40-fold enhancement of B. parapertussis colonization in the lungs. His data suggested that the vaccine may be contributing to the observed rise in whooping cough incidence over the last decade by promoting B. parapertussis infection.

Whooping Cough

An acellular whooping cough vaccine actually enhances the colonization of Bordetella parapertussis in mice; pointing towards a rise in B. parapertussis incidence resulting from acellular vaccination, which may have contributed to the observed increase in whooping cough over the last decade.

Despite widespread vaccination, whooping cough incidence is on the rise worldwide, making it a disease virtually immune to vaccines.

Read more:
http://www.thelibertybeacon.com/2014/02/10/vaccines-are-causing-mutations-that-may-jeopardize-the-health-of-future-generations/

SV-40 Deadly Cure
http://www.viewzone.com/sv40x.html

Advances in Virus Research, Volume 50

Pages 83 and 84, read. (Also see the study titled, Simian virus 40 in humans, below on this page)

Excerpted:

Moreover, blood and sperm fluid may represent important means for spreading of SV40 in humans.

Indeed in these investigations, (Martini etal;, 1995,1996) 61% of the neoplastic patients positive for SV 40 sequences were of an age excluding exposure to SV 40-contaminated polio vaccines, suggesting contagious transmission of SV 40 by horizontal infection.

http://books.google.com/books?id=PfO7D8ZoSMkC&pg=PA84&lpg=PA84&dq=sv40+is+contagious&source=bl&ots=AlaWsAkp95&sig=RnycQFX2ucD-3zybHQ07FAIeJYk&hl=en&sa=X&ei=kZLfT5_mA4qc2QXKz6jtCA&ved=0CFoQ6AEwBg#v=onepage&q=sv40%20is%20contagious&f=false

Simian virus 40 in humans

Fernanda Martini1, Alfredo Corallini2, Veronica Balatti1, Silvia Sabbioni2, Cecilia Pancaldi1 and Mauro Tognon1*

Corresponding author: Mauro Tognon

Author Affiliations

1 Department of Morphology and Embryology, Section of Cell Biology and Molecular Genetics, School of Medicine, and Center of Biotechnology, University of Ferrara, Via Fossato di Mortara, 64/B. 44100 Ferrara, Italy

2 Department of Experimental and Diagnostic Medicine, Section of Microbiology, University of Ferrara, Via Luigi Borsari, 46. 44100 Ferrara, Italy

Excerpted:

A source of human exposure to SV40 occurred between 1955 and 1963, when inactivated and live anti-polio vaccines, prepared from polioviruses grown in naturally SV40-infected simian cell cultures, were administered to hundreds of millions of people in the United States, Canada, Europe, Asia and Africa [63]. Soon it was shown that children vaccinated with contaminated oral polio vaccines (OPV) shed infectious SV40 in stools for at least 5 weeks after vaccination [64]. However, some children, who received the same OPV, did not develop neutralizing antibodies even though they may have received large doses of live SV40, compared with the potentially inactivated SV40 in inactivated polio vaccine (IPV). Further, SV40 human contamination occurred in experimental infection with live respiratory syncytial virus to adult volunteers and a neutralizing antibody response in about two thirds of the volunteers was shown [65]. Inactivated vaccines against adenoviruses [66] and hepatitis A [67] virus also exposed humans to SV40, although the amount of infectious SV40 was almost certainly lower then that administered with OPV or live respiratory syncytial virus.

Additional serologic studies reported a SV40 seropositivity in individuals with no history of immunization with contaminated IPV or other possible route of SV40 infection [69-72]. Shah et al., [72]

These studies suggest that humans may become infected by SV40 independently from poliovirus vaccine exposure. However, most of these early serologic studies were carried out before the discovery of the two human polyomaviruses, BK and JC, which are close related to SV40 and are ubiquitous in human populations. It is possible that the early serologic evidence of SV40 antibody detection in human sera represents some degree of cross reactivity with antibodies against the highly related BK and JC viruses [73-75].

To date, the prevalence of SV40 infections in humans is not known. Recent studies, based on PCR and serological techniques, indicate that SV40 infection occurs both in children and adults. (i) SV40 DNA sequences have been detected in normal and neoplastic tissues of people either too young (1 to 30 years) or too old (60 to 85 years) to have been vaccinated with SV40-contaminated anti-polio vaccines [19,33,76-81]. This finding may also explain the lack of difference in cancer incidence between individuals vaccinated with SV40-contaminated and SV40-free anti-polio vaccines [82]. (ii) SV40 sequences and Tag were detected in blood and sperm specimens from normal individuals and oncologic patients [80,81,83-88] and in lymphoblastoid cells [32]. These results suggest that (peripheral blood mononuclear cells) PBMCs, could be a reservoir and vehicle of SV40 spreading in the tissues of the host and among the individuals. (iii) SV40 sequences were found in urine and stoole samples, from children and adults [84,89,90], indicating that the haematic, sexual and orofecal routes of transmission are likely to be responsible for SV40 horizontal infection in humans.

http://www.infectagentscancer.com/content/2/1/13

SV40 and Cancer, Oral Presentation, Barbara Loe Fisher
Co-founder & President, National Vaccine Information Center
September 10, 2003

Subcommittee on Human Rights and Wellness
U.S. House Government Reform Committee
U.S. House of Representatives, Washington, D.C.

“The SV40 Virus: Has Tainted Polio Vaccine Caused An Increase in Cancer?”

http://www.nvic.org/nvic-archives/testimony/testimonyspetember102003.aspx

Infectious Agents and Cancer

Review Open Access

Simian virus 40 in humans

Abstract

Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells.

Recent molecular biology and epidemiological studies suggest  that SV40 may be contagiously transmitted in humans by horizontal infection, independently from the earlier administration of SV40-contaminated vaccines.

SV40 footprints in humans have been found associated at high prevalence with specific tumor types such as brain and bone tumors, mesotheliomas and lymphomas and with kidney diseases, and at lower prevalence in blood samples from healthy donors.

Contrasting reports appeared in the literature on the circulation of SV40 in humans by contagious transmission and its association, as a possible etiologic cofactor, with specific human tumors. As a consequence of the conflicting results, a considerable debate has developed in the scientific community. In the present review we consider the main results obtained by different groups investigating SV40 sequences in human tumors and in blood specimens, the putative role of SV40 in the onset/progression of specific human tumors, and comment on the hypotheses arising from these data.

http://www.biomedcentral.com/content/pdf/1750-9378-2-13.pdf

ORAL POLIO VACCINE AND HUMAN CANCER: A REASSESSMENT OF SV40 AS A CONTAMINANT BASED UPON LEGAL DOCUMENTS.

Abstract

To date, the scientific literature and research examining SV40 and cancer-related diseases has been based upon an assumption that SV40 was not present in any poliovirus vaccine administered in the United States and was removed from the killed polio vaccine by 1963. The basis for this presumption has been that the regulations for live oral polio vaccine required that SV40 be removed from the seeds and monovalent pools ultimately produced in the manufacturing process. The Division of Biologic Standards permitted an additional two tissue culture passages–from three to five–in order to allow manufacturers the ability to remove this contaminant from the oral poliovirus vaccines then awaiting licensure. The confirmation of the removal by one drug manufacturer, Lederle, has been made public at an international symposium in January 1997, where its representatives stated that all of Lederle’s seeds had been tested and screened to assure that it was free from SV40 virus. However, in litigation involving the Lederle oral polio vaccine, the manufacturer’s internal documents failed to reveal such removal in all of the seeds. The absence of confirmatory testing of the seeds, as well as testimony of a Lederle manager, indicate that this claim of removal of SV40 and the testing for SV40 in all the seeds cannot be fully substantiated. These legal documents and testimony indicate that the scientific community should not be content with prior assumptions that SV40 could not have been in the oral polio vaccine. Only further investigation by outside scientific and independent researchers who can review the test results claimed in the January 1997 meeting and who can conduct their own independent evaluations by testing all the seeds and individual mono-valent pools will assure that SV40 has not been present in commercially sold oral poliovirus vaccine manufactured by Lederle.

http://www.ncbi.nlm.nih.gov/pubmed/11205211

Simian virus 40 DNA found in US children:
http://www.dreddyclinic.com/findinformation/ww/dis_con_article_ww/wilms_tumor_1.htm

Simian Virus 40 Sequences in Human Lymphoblastoid B-Cell Lines:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140833/

Types of SV40 Associated Cancers:
http://www.sv40foundation.org/Types.html

Simian virus 40 is present in most United States human mesotheliomas, but it is rarely present in non-Hodgkin’s lymphoma.
http://www.ncbi.nlm.nih.gov/pubmed/10619511

Simian virus in polio shots tied to cancer / Two studies support widely disputed theory
http://www.sfgate.com/health/article/Simian-virus-in-polio-shots-tied-to-cancer-Two-2865997.php

Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961.
http://cancerres.aacrjournals.org/content/65/22/10273.long

Center for Complex Infectious Diseases:
http://www.ccid.org/addviruses/sv40.htm

Scientific proof that the known cancer causing SV40 virus, a previous contaminant in the polio vaccine, is obviously either contagious; or the virus is still in the vaccine/s.
http://www.vacfacts.info/scientific-proof-that-the-known-cancer-causing-sv40-virus-a-previous-contaminant-in-the-polio-vaccine-is-obviously-either-contagious-or-the-virus-is-still-in-the-vaccines.html

Vaccines Are Causing Mutations That May Jeopardize The Health of Future Generations

By: Dave Mihalovic

Vaccines are causing an unprecedented number of mutations creating superbugs and potent viruses and bacteria that may eventually threaten future generations and humanity itself. Evidence continues to mount from the scientific community who now admit that certain vaccines are in-fact causing both viral and bacterial mutations. Ironically, the same researchers assert that “better” vaccines are needed to offset the rise in persistent mutations.

Life-threatening pathogens are capable of evolving rapidly and developing genetic decoys that serve to disguise them from even the most powerful drugs. University of Oxford researcher Rory Bowden found that pathogens switch genetic material with other bacteria, but predominantly for the part of the genome responsible for making the cell coating, which is the area targeted by vaccines.

Former post-doctoral researcher of the Center for Infectious Disease Dynamics, Grainne Long found that vaccination led to a 40-fold enhancement of B. parapertussis colonization in the lungs. His data suggested that the vaccine may be contributing to the observed rise in whooping cough incidence over the last decade by promoting B. parapertussis infection.

Whooping Cough

An acellular whooping cough vaccine actually enhances the colonization of Bordetella parapertussis in mice; pointing towards a rise in B. parapertussis incidence resulting from acellular vaccination, which may have contributed to the observed increase in whooping cough over the last decade.

Despite widespread vaccination, whooping cough incidence is on the rise worldwide, making it a disease virtually immune to vaccines.

Read more:
http://www.thelibertybeacon.com/2014/02/10/vaccines-are-causing-mutations-that-may-jeopardize-the-health-of-future-generations/

Vaccine Contamination
http://www.vacfacts.info/vaccine-contamination.html

The Current Failure of Pertussis and Measles Vaccine, measles and pertussis will never be eradicated with vaccines, due to vaccine shedding, and waning immunity thus preventing any real herd immunity.http://www.vacfacts.info/the-current-failure-of-pertussis-and-measles-vaccine.html​

V. Thirty Years of Rapidly Decreasing Vaccination in Leicester, and its Teachings.
http://www.vaclib.org/legal/MTstate/smallpox.pdf

Failure Of The Continued Polio Vaccine Campaign
http://www.vacfacts.info/failure-of-the-continued-polio-vaccine-campaign.html

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