Informed Citizens Against Vaccination

http://informedcitizensagainstvaccination.blogspot.nl/2009/11/polysorbate-80-aka-tween-80-allows.html

“A necessay forum of explanation for the anti vaccination perspective and reasoning: that vaccinations have never eradicated any diseases including poliomyelitis, are ineffective at preventing disease currently, and are shockingly hazardous to human health. We present these ideas through information taken from the most typically pro vaccine forums, such as the CDC and FDA, the vaccine product monographs and scientific studies published in reputable medical journals.”

FRIDAY, NOVEMBER 6, 2009

Polysorbate 80 aka “Tween 80”: Allows Vaccine Toxins to Cross the BBB, Anaphylaxis risk also

http://www.sailhome.org/Concerns/Vaccines.html

Emulsifiers

Generally listed as Polysorbate 80 or 20, these chemicals have an ability toincrease cell permeability, damage, and bursting. After injection they can rapidly metabolize into sorbitol and ethylene oxide which is much more toxic than the original chemical. When Polysorbate 80 breaks down there are 20 moles of ethylene oxide for every mole of sorbitol. These polysorbates have been shown to cause dangerous, sometimes fatal effects, when given through a needle. Changes in heart function can occur immediately. The blood-brain-barrier (BBB) can be weakened and penetrated, followed by seizures and even death. Anaphylactic and otherreactions can occur. Infants are particularly susceptible. These polysorbates also demonstrate synergistic toxicity with a range of chemicals including lindane, thalidomide — even Polymyxin B. ((ICAV notes: polymyxyin b is also a vaccine ingredient))

http://infertility.suite101.com/article.cfm/polysorbate_80_causes_infertility

Polysorbate 80 (also known as tween 80) is a stabilizer used in a wide variety of products including ice cream, milk products, vitamin tablets, lotions and creams and medical products like vaccines and anti-cancer medications.

It is toxic and should not be eaten, drunk, put on the skin or injected.

According to Annals of Allergy, Asthma and Immunology, Volume 95, Number 6, December 2005 , pp. 593-599(7), “it is of current relevance as a ‘hidden’ inductor of anaphylactoid reactions”, and “Polysorbate 80 was identified as the causative agent for the anaphylactoid reaction of nonimmunologic origin in the patient. Conclusions: Polysorbate 80 is a ubiquitously used solubilizing agent that can cause severe nonimmunologic anaphylactoid reactions.”

Put in plain English, polysorbate 80 can affect your immune system and cause severe anaphylactic shock which can kill.

http://www.drugs.com/cdi/darbepoetin-alfa-polysorbate-80.html

Clinical studies have shown Darbepoetin Alfa (Polysorbate 80) to increase the risk of serious side effects (eg, blood clots, stroke, heart attack, heart failure) and death in some cases. It has also been shown to shorten overall survival and/or increase the risk of tumor growth or recurrence in patients with certain types of cancer. Talk with your doctor about the risks and benefits of using Darbepoetin Alfa (Polysorbate 80) . Do not use more than the recommended dose without checking with your doctor.

http://www.associatedcontent.com/article/907819/polysorbate_80_in_vaccines_a_potentially.html?cat=70

Polysorbate 80 in Vaccines – A Potentially Toxic Vaccine Stabilizer

Polysorbate 80 in vaccines has become a controversial topic. According to the MSDS sheet at Science lab.com, section 11: Toxicological Information, it was tested for inhalation and ingestion and was shown to be slightly hazardous on skin contact, ingestion and inhalation. however these are minor compared to other potential side effects of it’s use especially in an intravenous or immunologic setting.

In the same section of toxicological information it states that it may cause reproductive effects, it may cause cancer, and may be a mutagenic, (change the genetics), in animals but this is followed up with the statement, no human data found. Well, unless they use people as lab rats, they won’t find this data until it is used on humans to an extent to present this data.

According to PubMed.Gov a service of the U.S. Library of Medicine and the National Institute of Health, a report shows that neonatal rats were injected with small doses of polysorbate 80 and the results were major effects on the reproductive organs of the rats, resulting in infertility. (see the PubMed link below). Considering this is a component of the GardasilHPV vaccine, (not to mention other vaccines), and they are recommending this to girls at prepubescent ages, there should be some concern to any parent that this could possibly lead to infertility in your child.

The Blood Brain Barrier: information

http://faculty.washington.edu/chudler/bbb.html

Functions of the BBB

The BBB has several important functions:
Protects the brain from “foreign substances” in the blood that may injure the brain.
Protects the brain from hormones and neurotransmitters in the rest of the body.
Maintains a constant environment for the brain.

The BBB can be broken down by:
Hypertension (high blood pressure): high blood pressure opens the BBB.
Development: the BBB is not fully formed at birth.
Hyperosmolitity: a high concentration of a substance in the blood can open the BBB.
Microwaves: exposure to microwaves can open the BBB.
Radiation: exposure to radiation can open the BBB.
Infection: exposure to infectious agents can open the BBB.
Trauma, Ischemia, Inflammation, Pressure: injury to the brain can open the BBB.

http://en.wikipedia.org/wiki/Blood-brain_barrier

The blood-brain barrier (BBB) is a separation of circulating blood andcerebrospinal fluid (CSF) maintained by the choroid plexus in the central nervous system (CNS). Endothelial cells restrict the diffusion of microscopic objects (e.g. bacteria) and large or hydrophilic molecules into the CSF, while allowing the diffusion of small hydrophobic molecules (O2, hormones, CO2). Cells of the barrier actively transport metabolic products such as glucose across the barrier with specific proteins.

This “barrier” results from the selectivity of the tight junctions betweenendothelial cells in CNS vessels that restricts the passage of solutes. At the interface between blood and brain, endothelial cells and associated astrocytes are stitched together by these tight junctions, which are composed of smaller subunits, frequently dimers, that are transmembrane proteins such as occludin, claudins, junctional adhesion molecule (JAM), ESAM and others. Each of these transmembrane proteins is anchored into the endothelial cells by another protein complex that includes zo-1 and associated proteins.The blood-brain barrier is composed of high density cells restricting passage of substances from the bloodstream much more than endothelial cells in capillaries elsewhere in the body. Astrocyte cell projections called astrocytic feet (also known as “glia limitans“) surround the endothelial cells of the BBB, providing biochemical support to those cells. The BBB is distinct from the similar blood-cerebrospinal fluid barrier, a function of the choroidal cells of the choroid plexus, and from the blood-retinal barrier, which can be considered a part of the whole.[1]

————————————————————————————–

author’s translation: the BBB keeps bad stuff out of the brain. Polysorbate 80 or “tween 80” in crossing the blood brain barrier, serves as a mode of transport for both positive chemicals to enter the brain (to aide in healing disease), as well as negative ones (such as the toxins in vaccinations). Shockingly enough, although polysorbate 80 is being used to aide other chemicals access beyond the BBB that would not normally be able to get through, absolutely no research has been done on whether polysorbate 80 in vaccinations also allows the chemicals of vaccinations to cross the BBB as well.

Studies on polysorbate 80 crossing the blood brain barrier (permeability):

Olivier JC, Fenart L, Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity. Pharm Res. 1999 Dec;16(12):1836-42.

Kreuter J, Ramge P, Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles.Pharm Res. 2003 Mar;20(3):409-16.

Alyautdin RN, Petrov VE, Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles.Pharm Res. 1997 Mar;14(3):325-8.

Gao K, Jiang X.Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Int J Pharm. 2006 Mar 9;310(1-2):213-9.

Wilson B, Samanta MK, Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles. Eur J Pharm Biopharm. 2008 Sep;70(1):75-84

Studies of polysorbate 80 and anaphylaxis:

Coors EA, Seybold H, Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions. Ann Allergy Asthma Immunol.2005 Dec;95(6):593-9.

CONCLUSIONS: Polysorbate 80 is a ubiquitously used solubilizing agent that can cause severe nonimmunologic anaphylactoid reactions

Julia M.L. Brotherton, MD MPH, Mike S. Gold, MD, Anaphylaxis following quadrivalent human papillomavirus vaccination. CMAJ • September 9, 2008; 179 (6).

(this article *does* specify polysorbate 80 in the details as the causative agent of anaphylaxis)

Neal A. Halsey, MD The human papillomavirus vaccine and risk of anaphylaxis, CMAJ • September 9, 2008; 179 (6).

Marléne Isaksson and Lennart Jansson, Contact allergy to Tween 80 in an inhalation suspension, Contact Dermatitis Volume 47 Issue 5, Pages 312 – 313. Jan 2003

Price, Kursteen S.1; Hamilton, Robert G, Anaphylactoid reactions in two patients after omalizumab administration after successful long-term therapy, Allergy and Asthma Proceedings, Volume 28, Number 3, May-June 2007 , pp. 313-319

Excerpt: The in vitro and in vivo immunologic data support the conclusion that the adverse reactions experienced by two patients after omalizumab administration after more than a year of successful omalizumab therapy for asthma were likely anaphylactoid in nature. Polysorbate, an excipient in omalizumab, is known to cause similar reactivity to other medicines and is the most likely cause of these reactions.

http://www.sailhome.org/Concerns/Vaccines/MAC.html

Understanding the mechanism of detergents (polysorbate 80) in the human body:

Injected detergents trespass on an immune process that holds life and death control over cells… There are two major aspects to the body’simmune system:
• The ‘adaptive‘ immune system — this includes various lymphocytes, such as B cell and T cells, and antibodies
• The ‘innate‘ immune system — this includes various leukocytes, such as phagocytes and natural killer cells, and the use of inflammation and the Complement system

The Complement system is a chain-reaction of biochemical events that help remove pathogens from the body. The Membrane Attack Complex (MAC) is part of the Compliment system — and it is one of the immune system’s ultimate weapons.

When an invading pathogen is identified, signals are sent causing MAC proteins to collect onto the pathogen’s surface membrane. These proteins form ring structures which tunnel through the membrane. In other words, the MAC puts holes in the invading cell. These holes cause the cell to leak or explode by weakening its membrane. The cell dies quickly. Killing cells by punching holes into them makes the MAC extremely potent — and also extremely destructive if it runs out of control. For this reason the MAC (and the Complement system in general) is tightly regulated by additional proteins. Detergents are used during the manufacture of flu vaccines. These chemicals are not completely purified out of the final product, so they enter the body at the time of injection.

Understanding the MAC helps explain the harm caused by injected detergents. Just like the MAC, detergents cause cells to leak or explode. But detergents are unregulated. Detergents act like the MAC out of control. The MAC targets foreign cells and avoids self-cells — detergents hit cells at random. The MAC responds to signals which call off the attack — detergents continue destroying cells. The MAC is integrated into the complex (and sensitive) signaling and feedback relationships between the Compliment system, the overall immune system, and other bodily functions in general — detergents are foreign to these relationships and disrupt them.

The MAC operates as part of the Complement system. When activated, the Complement system triggers events such as:

• Increased arachidonic acid metabolism leading to acute inflammation and damage to nearby tissue
• Histamine release with its effects on allergic response, digestion, and neurotransmitter function
• Pyrogen release and the onset of fever

These are normal immune responses, but autoimmune disorders and other diseases arise when the responses become overactive. Examples of illnesses directly linked to severe MAC activity include:

Demyelination
Microvascular injury leading to blindness, kidney failure, and neuropathy
Progressive muscle damage (dysferlinopathy)
Beta-amyloid growth and Alzheimer’s disease
Reperfusion injury (for instance following heart failure or stroke)
Myasthenia gravis
Brain swelling

These maladies illustrate the consequences of MAC overactivity — and hence illustrate consequences to be expected from injected detergents. Detergents represent the worst kind of autoimmune dysfunction — they randomly destroy *any* kind of host cell with no mechanism for regulating destructive activity.

As mentioned above, the MAC is regulated by certain proteins. One of these proteins is labeled CD59. It protects a host cell by binding to its surface and preventing MAC structures from assembling. Loss of CD59 protection leaves the cell vulnerable to damage and lysis (a ruptured membrane).

Here are some examples of conditions directly linked to loss of CD59:

Damaged neuromuscular transmission junctions
Rheumatoid arthritis
Kidney disease
Stroke
Fatal cerebral hemorrhage

These conditions indicate the kind of damage that can be done by injected detergents — they have no regard for cells protected by CD59 or other regulating proteins. How fast do detergents leave the body? Do they just keep causing damage until they are somehow metabolized and eliminated? Carrying out studies to investigate the metabolic fate of detergents injected into humans would be unethical. Clues must be gathered from other kinds of studies in order to understand the rate at which injected detergents leave the body.

These studies indicate:
• Detergents are not easily metabolized and may remain in the system for lengthy periods
• Elimination is dependent on P450 enzymes and the liver — which may also be damaged in the process
• Breakdown products include octylphenols which:
Are more persistent
Are endocrine disruptors
Depress immune function
Deplete glutathione
Induce cell death (apoptosis)
Pass through breast milk

According to GlaxoSmithKline a 0.5 ml dose of Fluarix may contain up to 0.085 mg of Triton X-100. It proved too difficult to find the specific gravity for Fluarix so calculating the level of Triton X-100 in parts per million (ppm) isn’t easily possible. However, this gives the molecular weight of Triton X-100 as 250.376 g/mol. That’s 200 thousand trillion molecules of Triton X-100 injected in a dose. That’s an opportunity for trillions of self-cells to be injured or killed by the detergent, resulting in symptoms and diseases in line with what is described above. Exposure is likely to be similar with other vaccines containing detergents. If someone has a SNP (single nucleotide polymorphism) of -/+, +/-, or -/- for HGNC:1689expression of CD59 they may be especially vulnerable to disruptions and damage caused by detergents. SNPs in other Complement system regulators would also make a person more vulnerable to these effects.

Normally, phagocytes consume injured cells, dead cells and their fragments after MAC activity. But phagocytosis will not necessarily take place after a self-cell is injured (not completely destroyed) by a detergent. Just postulating for a moment: What if the detergent weakens but does not destroy a cell. And what if this injured cell (perhaps it’s a stem cell) becomes cancerous? Further, what if this cell is self-protected by CD59 or other control proteins? In that scenario the self-protected cancer cell could have favorable conditions to proliferate. That would offer a mechanism for explaining why detergents have been observed to promote tumors (as citedhere). That idea is not so far-fetched when considering that cancer cellsexpress CD59 and other MAC inhibitors. Sea anemones and malaria-transmitting mosquitoes also make use of MAC-like proteins to breachtheir victim’s cells. It has been demonstrated that antibiotics work by disrupting cell membranes, too.

Detergents are used extensively in cell research precisely because of their ability to break cells open for further analysis.

Does it really make sense to knowingly inject these chemicals into pregnant women, babies, children, the immune compromised, the elderly — or anyone else?

A note on Polysorbate 20- found in the Havrix vaccine (this is much weaker than polysorbate 80 it turns out)

http://www.associatedcontent.com/article/906301/toxic_chemicals_in_vaccines_polysorbate.html?cat=58

A Slightly Toxic Emmulsifier and Delivery Vehicle for Antigens

Polysorbate 20 is only Mildly toxic as compared to many of the vaccine ingredients. According to the MSDS sheet it is slightly hazardous in short term contact and may be an irritant to skin and eyes, as well as inhalation and ingestion. There is no available information pertaining to it’s carcinogenic, Mutagenic, Teratogenic effects or developmental effects.Unlike polysorbate 80, it appears as though polysorbate 20 is relatively safe, at least with the limited research into it.

My biggest concern with ingredients that show mild irritation to skin and eyes is that these contact exposures differ widely from injected polysorbate 20 in vaccines exposure. Skin and eye contact are presumably washed off before or when irritation occurs, where as if this ingredient causes internal irritation not only may it go unnoticed, but you cannot wash it away. It will not be filtered out by the normal biological processes since it was not introduced into the body through normal exposure.Polysorbate 80 has been shown to cause infertility in mice, which will be covered in the polysorbate 80 article, but polysorbate 20 is a family chemical even though it is different. I certainly would feel better about this ingredient than I do most of the ingredients I have written on so far. The only vaccine I’ve found polysorbate 20 in is the Havrix Hepatitis A vaccine manufactured by GlaxoSmithKline

MSDS:

http://www.sciencelab.com/xMSDS-Polysorbate_20-9926640

Informed Choice:

http://www.informedchoice.info/cocktail.html

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